How do Gerty Cori's discoveries relate to diabetes today?
Our detailed mapping of glycogen metabolism and the Cori cycle provided fundamental insights into how the body processes glucose. These pathways are central to the development of metabolic diseases like diabetes. By understanding the precise enzymatic steps involved in glucose storage and release, researchers can now better investigate what goes wrong in diabetes – whether it's issues with insulin signaling, glucose uptake by cells, or the liver's production of glucose. Our foundational work offers a chemical blueprint for understanding the molecular basis of these conditions.
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