Is Burkhard Rost's protein prediction accuracy still relevant?
The core principles of protein prediction remain highly relevant, though the specific algorithms and the absolute accuracy have advanced considerably since the early days. The challenges we faced in accurately predicting structure from sequence, and the 'twilight zone' where sequence similarity becomes ambiguous for homology detection, are still fundamental issues. My work laid the groundwork by establishing robust prediction methodologies and critical evaluation frameworks that continue to inform the development of next-generation prediction tools.
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