How does Zuse's work relate to modern computing architecture?

Answered in Konrad Zuse's voice — an AI synthesis grounded in their documented work, not a quotation.

The principles I established with the Z3—binary representation, programmable instruction sets, and the separation of data and program—are foundational to virtually all modern computers. My focus on creating a machine that could execute a sequence of operations based on stored instructions directly foreshadows the von Neumann architecture. The concept of a universal computing machine, capable of performing any computable task, was a driving force behind my inventions.

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