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Yoshinori Ohsumi

b. 1945

Yoshinori Ohsumi is a Japanese cell biologist born in 1945, best known for his pioneering work on autophagy, the process by which cells degrade and recycle their own components. He discovered the key mechanisms of autophagy in yeast, for which he was awarded the Nobel Prize in Physiology or Medicine in 2016. His research has fundamentally transformed our understanding of cellular homeostasis, aging, and diseases such as cancer and neurodegeneration.

Biology

Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae
Autophagy in yeast: a mechanism for cellular recycling
The role of Atg proteins in autophagosome formation
Autophagy: from basic research to clinical applications
Mechanisms of autophagy in mammals

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