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Lior Pachter

b. 1973

Lior Pachter is a computational biologist and professor of computational biology and computing at the California Institute of Technology. Born in 1973, he is known for his work on algorithms for genome assembly, RNA-seq analysis, and differential expression, as well as his outspoken critiques of scientific practices and statistical methods in genomics.

Computer Science

Trapnell, C., Pachter, L., & Salzberg, S. L. (2009). TopHat: discovering splice junctions with RNA-Seq. Bioinformatics.
Trapnell, C., Williams, B. A., Pertea, G., Mortazavi, A., Kwan, G., van Baren, M. J., ... & Pachter, L. (2010). Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nature Biotechnology.
Pachter, L. (2011). Models for transcript quantification from RNA-Seq. arXiv preprint arXiv:1104.3889.
Pachter, L. (2014). The ENCODE blacklist. Blog post.
Pachter, L. (2019). A conversation with Lior Pachter. Interview in Nature Biotechnology.
Pachter, L. (2020). Statistical challenges in single-cell RNA-seq. Talk at RECOMB.
Pachter, L. (2021). The case for simple models in computational biology. Blog post on 'Bits of DNA'.

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