The Study of Elementary Particles by the Photographic Method (1949)

Question

Explain how Bose's discovery of "electric response of non-living matter" exhibiting fatigue, enhancement, and abolition directly served as a foundational argument for his later hypothesis about the physico-chemical basis of living matter's responses.

Synthesized answer

Bose’s discovery that non-living matter (metals) exhibits fatigue, enhancement, and abolition under stimulation directly supported his hypothesis that living matter’s responses are fundamentally physico-chemical. He showed that metals, like living tissues, display fatigue under continuous stimulation, enhancement under chemical stimulants, and permanent abolition under poisons [1]. These parallels indicated that “the response of the more complex and unstable living matter is ultimately the expression of physico-chemical reactions” [1].

Further experiments reinforced this unity: the same chemical reagent in large doses depresses excitability and abolishes response in metals, while minute doses greatly enhance response—a pattern also seen in living plants, where poisons in small doses act as stimulants for growth [2]. Similarly, continuous stimulation induces fatigue in inorganic receivers, removed by rest, and prolonged rest makes them inert until re-stimulated—characteristics “similar to those in the response of living substance” [3]. Bose concluded that phenomena like negative variation, stimulus-response relations, and effects of stimulants and poisons are “curiously like the…

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From the book

bject of my inquiry was the optical properties of Electric Waves, brought down to within a few octaves of visible light. In the course of my investigations I was led to the discovery of electric response of non-living matter, such as metals, an account of which was published in 1900 by the International Congress of Science, Paris. The response, like that of living matter, was shown to exhibit fatigue under continuous stimulation, enhancement under chemical stimulants, and permanent abolition under poisons. These results indicated that the response of the more complex and unstable living…
Passage [4]
onding substance can absorb the whole amount of incident stimulus, the first moiety absorbed being sub-minimal (p. 181). This characteristic effect is exhibited not only by electromagnetic receivers (p. 189) but also by photo-electric cells responding to light (p. 190) and by strain cells under mechanical stimulation (p. 204). In plants also similar reactions are observed. This is seen in the opposite effects of feeble and strong intensity of electric waves in enhancement and retardation of growth respectively (p. 355). ​ Parallel effects are also observed in regard to chemical stimulation of…
Passage [117]
ulting effect does not solely depend on the total quantity of incident light, but also on the time-rate of illumination. Hence for the same duration of exposure, the photographic effects of intermittent and continuous illuminations are not the same (p. 217). D. The Similarity of Response of Inorganic and Living Substances A molecular upset is produced in inorganic substances by the impact of stimuli, electrical or mechanical. The response is recorded by methods of conductivity and electromotive variations. In inorganic receivers for electric radiation, continuous stimulation induces fatigue…
Passage [103]
osition of stimuli causes incomplete or complete "tetanus" according to slow or quick frequency of stimulation (p. 256). ​ Certain chemical substances produce a great enhancement in the amplitude of response; these act as stimulants in inducing an increase of excitability (p. 274). Others produce a depression. The variation of excitability induced by various chemical substances, or different doses of the same substance can be detected by the Electric Comparator (p. 282). Slight differences of physico-chemical change in the same piece of metal are detected and recorded by the Electra-molecular…
Passage [104]
ortions are rendered unequal. Hence a responsive electromotive variation is obtained by stimulating the wire as a whole. The current in the wire is from the less to the more excitable. 13. This method enables the detection of invisible traces of physico-chemical change in a wire. 14. Chemical reagents not only change the excitability but also the quickness of response. Two points having two different rates thus give diphasic and other interference effects. ( Proc. Roy. Soc. May 1902.) ↑ The various phenomena connected with the response in inorganic substances—the negative variation—the…
Passage [262]

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